The Week in Brief
- Nasdaq-100 (QQQ) rose 0.9% while the Dow Jones (DIA) fell 1.9%; S&P 500 (SPY) declined 0.3%
- Health Care (XLV) led with a 1.8% gain; Financials (XLF) and Utilities (XLU) lagged, down 2.4% and 3.0%
- Breadth tilted negative: 587 advancers, 1,370 decliners; median stock fell 1.6%
- Schrodinger Inc ($SDGR) led all stocks, gaining 52.6%; Alignment Healthcare Inc ($ALHC) fell 33.8%
- Strategy Inc ($MSTR) rose 17.5%, pacing large-cap gainers; Constellation Energy Corp ($CEG) dropped 10.6%
U.S. equity indices diverged sharply for the week ending September 18, with the Nasdaq-100 (QQQ) advancing 0.9% to close at $721.45 while the Dow Jones (DIA) fell 1.9% to $515.88. The S&P 500 (SPY) declined 0.3% to $761.69, and the Russell 2000 (IWM) dropped 1.7% to $284.10. Breadth was negative across the 1,963-stock universe, with 587 advancers and 1,370 decliners; the median stock fell 1.6%. Treasuries (TLT) and gold (GLD) both rose modestly, adding 0.5% and 0.6% respectively, while crude oil (USO) declined 0.7%.
Index & Asset Scoreboard
Weekly price change of the major index and asset-class ETFs, Friday close to Friday close.
| Instrument | Sep 18 close | Week |
|---|---|---|
| S&P 500 (SPY) | $761.69 | ▼-0.34% |
| Nasdaq-100 (QQQ) | $721.45 | ▲+0.92% |
| Dow Jones (DIA) | $515.88 | ▼-1.88% |
| Russell 2000 (IWM) | $284.10 | ▼-1.66% |
| 20+ Yr Treasuries (TLT) | $81.25 | ▲+0.47% |
| Gold (GLD) | $401.17 | ▲+0.60% |
| Crude Oil (USO) | $153.82 | ▼-0.70% |
Sector Rotation
Health Care (XLV) led all sector ETFs with a 1.8% gain, followed by Technology (XLK) at 1.0%. The defensive tilt did not extend beyond these two: Consumer Staples (XLP) declined 0.7%, while cyclicals lagged sharply. Financials (XLF) fell 2.4%, Utilities (XLU) dropped 3.0%, and Real Estate (XLRE) declined 2.1%. Sector breadth told a similar story. Health Care saw 149 of 297 stocks advance, averaging a 0.8% gain, while Consumer Discretionary registered only 37 of 216 advancers and averaged a 3.4% decline. Energy and Materials also posted broad weakness, with fewer than one-third of stocks advancing in each.
Left: the ten SPDR sector ETFs ranked by weekly price change. Right: breadth inside each sector across the screened universe — how many of its stocks rose, and the average move.
| Sector ETF | Week |
|---|---|
| Health Care (XLV) | ▲+1.83% |
| Technology (XLK) | ▲+1.03% |
| Consumer Staples (XLP) | ▼-0.70% |
| Energy (XLE) | ▼-1.27% |
| Industrials (XLI) | ▼-1.52% |
| Consumer Disc. (XLY) | ▼-1.71% |
| Materials (XLB) | ▼-1.88% |
| Real Estate (XLRE) | ▼-2.05% |
| Financials (XLF) | ▼-2.43% |
| Utilities (XLU) | ▼-3.04% |
| Sector (stocks) | Adv / Total | Avg move |
|---|---|---|
| Health Care | 149 / 297 | +0.84% |
| Information Technology | 116 / 265 | -0.01% |
| Consumer Staples | 27 / 87 | -1.02% |
| Industrials | 95 / 320 | -1.58% |
| Utilities | 7 / 61 | -2.00% |
| Financials | 67 / 341 | -2.04% |
| Real Estate | 22 / 107 | -2.08% |
| Communication | 21 / 74 | -2.18% |
| Energy | 27 / 99 | -2.69% |
| Materials | 18 / 94 | -2.74% |
| Consumer Discretionary | 37 / 216 | -3.38% |
Top 10 Winners
Schrodinger Inc ($SDGR, Health Care) topped the weekly leaderboard with a 52.6% gain to $29.02. Tempus AI Inc ($TEM, Health Care) rose 31.9% to $77.84, and Twist Bioscience Corp ($TWST, Health Care) gained 31.3% to $166.99. Among large-caps, Strategy Inc ($MSTR, Information Technology) rose 17.5% to $153.92 on what a tracked September 18 headline described as growing digital asset adoption with a new catalyst looming next week. CrowdStrike Holdings Inc ($CRWD, Information Technology) advanced 15.0% to $237.65, and Coinbase Global Inc ($COIN, Financials) gained 10.8% to $194.25 after a tracked September 18 headline noted the company embedded its rails inside more than 4,000 community banks. On the downside, Alignment Healthcare Inc ($ALHC, Health Care) fell 33.8% to $8.35, and Xenon Pharmaceuticals Inc ($XENE, Health Care) declined 32.2% to $39.75. Among large-caps, Constellation Energy Corp ($CEG, Utilities) dropped 10.6% to $254.71, Corning Inc ($GLW, Information Technology) fell 9.8% to $150.13, and Comcast Corp ($CMCSA, Communication) declined 9.8% to $22.74.
Largest weekly gains among US-listed stocks with market cap above $1B and share price above $5. Context shows the week's earnings result and latest tracked headline where available.
Biggest gainers · Sep 11–Sep 18
| Symbol | Week | Context |
|---|---|---|
| SDGRSchrodinger Inc$29.02 | ▲+52.58% | — |
| TEMTempus AI Inc$77.84 | ▲+31.91% | — |
| TWSTTwist Bioscience Corp$166.99 | ▲+31.26% | — |
| RUMRumble Inc$9.09 | ▲+26.78% | — |
| CAICaris Life Sciences Inc$29.98 | ▲+23.17% | — |
| RBRKRubrik Inc$106.71 | ▲+23.15% | — |
| EVCMEverCommerce Inc$7.77 | ▲+23.14% | — |
| ZSZscaler Inc$197.31 | ▲+19.92% | — |
| IOVAIovance Biotherapeutics Inc$10.25 | ▲+19.19% | — |
| WGSGeneDx Holdings Corp$101.10 | ▲+18.57% | — |
Top 10 Losers
Largest weekly declines on the same screen.
Biggest decliners · Sep 11–Sep 18
| Symbol | Week | Context |
|---|---|---|
| ALHCAlignment Healthcare Inc$8.35 | ▼-33.78% | — |
| XENEXenon Pharmaceuticals Inc$39.75 | ▼-32.23% | — |
| FLNCFluence Energy Inc$7.32 | ▼-26.28% | — |
| ENVAEnova International Inc$174.72 | ▼-21.82% | — |
| VYXNCR Voyix Corp$6.74 | ▼-21.17% | — |
| ARWRArrowhead Pharmaceuticals Inc$66.48 | ▼-19.76% | — |
| IONSIonis Pharmaceuticals Inc$44.44 | ▼-18.02% | — |
| ANAutoNation Inc$168.29 | ▼-17.37% | — |
| GENIGenius Sports Ltd$5.64 | ▼-17.30% | — |
| AMRAlpha Metallurgical Resources Inc$174.22 | ▼-16.80% | — |
Large-Cap Movers
The same ranking restricted to companies above $50B in market cap — the names most likely to sit in index funds and 401(k)s.
Large-cap gainers
- MSTRStrategy Inc · $51.0B▲+17.52%
- CRWDCrowdStrike Holdings Inc · $243.3B▲+14.95%
- COINCoinbase Global Inc · $51.3B▲+10.84%
- PANWPalo Alto Networks Inc · $275.9B▲+9.96%
- SNDKSandisk Corp · $239.2B▲+9.70%
Large-cap decliners
- CEGConstellation Energy Corp · $93.7B▼-10.55%
- GLWCorning Inc · $132.9B▼-9.78%
- CMCSAComcast Corp · $80.7B▼-9.76%
- SLBSLB NV · $83.2B▼-8.81%
- GSGoldman Sachs Group Inc · $302.4B▼-8.47%
Earnings Movers
Thirteen stocks in the screened universe reported earnings during the week, and post-earnings reactions varied. The largest gain came from Nordic American Tankers Ltd ($NAT, Energy), which rose 10.6% to $8.25 after beating EPS estimates by 66.8%. GameStop Corp ($GME, Consumer Discretionary) gained 7.0% to $22.64 despite missing estimates by 1.0%. On the downside, RH ($RH, Consumer Discretionary) fell 5.6% to $126.54 despite beating EPS by 20.8%, and Lennar Corp ($LEN, Consumer Discretionary) declined 4.0% to $76.43 after missing estimates by 6.5%. The pattern showed limited correlation between the size of earnings surprises and subsequent stock moves.
13 companies in the screen reported quarterly results this week. These are the largest weekly moves among them, with the EPS surprise that accompanied them.
Biggest gains after reporting
| Symbol | Act / Est | Surprise | Week |
|---|---|---|---|
| NATNordic American Tankers Ltd | $0.32$0.19 | +66.8% | ▲+10.59% |
| GMEGameStop Corp | $0.27$0.27 | -1.0% | ▲+7.04% |
| KMTSKestra Medical Technologies Ltd | $-0.75$-0.63 | -19.4% | ▲+6.91% |
| TRAXFirst Tracks Biotherapeutics Inc | $-0.95$-0.85 | -12.0% | ▲+5.93% |
| ZGNErmenegildo Zegna NV | $0.09$0.16 | -44.3% | ▲+5.86% |
Biggest declines after reporting
| Symbol | Act / Est | Surprise | Week |
|---|---|---|---|
| RHRH | $0.53$0.44 | +20.8% | ▼-5.62% |
| LEN.BLennar Corp | $1.23$1.32 | -6.5% | ▼-4.55% |
| LENLennar Corp | $1.23$1.32 | -6.5% | ▼-3.98% |
| AMCRAmcor PLC | $1.23$1.22 | +1.2% | ▼-0.99% |
| MMacy's Inc | $0.40$0.38 | +5.9% | ▼-0.63% |
Methodology & Disclaimer
Data. All figures come from Money365.Market's own daily price, earnings and analyst-recommendation records, captured at each US close. Returns are price returns from the Sep 11 close to the Sep 18 close; dividends are excluded.
Screen. 1,963 US-listed common stocks with market capitalization of at least $1B and a closing price of at least $5, with prices on at least three of the week's 5 trading days. ETFs and funds are excluded from the stock rankings.
Adjustments. Weekly moves are compounded from daily changes and cross-checked against closing prices; where the two disagree (stock splits, data corrections) the smaller move is used and the row is marked with an asterisk.
Narrative. The short prose sections were drafted by an AI model from the verified data above only, then checked automatically for number and ticker traceability, editorial tone and FCA financial-promotion wording before publication.
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